The Science of Reverse Aging
Aging follows a sequence.
Which means it can be interrupted—in reverse order.
Why skin aging occurs through five pathways.
Removing senescent cells. Claiming skin longevity. Declaring reverse aging. The major brands are planting their flags one after another. But every one of them addresses only a single aspect of aging.
Targeting one cause does not stop the cascade. Skin aging advances through five interconnected pathways—and each one feeds the next.
Understanding these five pathways is where real reverse aging begins.
The Aging Cascade
Five pathways.
This is the sequence in which skin ages.
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ROS (Reactive Oxygen Species)
The origin of the cascade. When this goes unchecked, everything begins.
Reactive oxygen species (ROS), generated by UV exposure, stress, and environmental pollution, oxidize cells and DNA. This is the trigger that initiates the entire skin aging cascade. Controlling ROS means cutting the chain of aging at its root.
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Chronic Inflammation
A slow fire ignited by ROS. The skin deteriorates before you notice.
When ROS accumulates, chronic low-grade inflammation takes hold inside the skin. Inflammation is also the breeding ground for senescent cells. Controlling the inflammation that produces senescent cells is a more fundamental approach than removing them after the fact.
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MMP & Fibroblasts
Inflammation activates the enzymes that dismantle the skin's scaffolding.
Chronic inflammation activates MMPs (matrix metalloproteinases)—enzymes that break down collagen and elastin, dismantling the structural scaffolding of the skin. Simultaneously, fibroblasts, the cells responsible for producing collagen, begin to lose their function.
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Barrier Function & Collagen
The accumulated destruction by MMPs surfaces as wrinkles and sagging.
As collagen is lost, skin loses firmness and elasticity. Barrier function breaks down alongside it, reducing resistance to external stressors. When the barrier is compromised, even the most expensive ingredients applied topically have limited reach.
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AGEs (Advanced Glycation Endproducts)
The skin stiffens with accumulation. Once formed, AGEs do not reverse.
AGEs, formed when sugars bind to proteins, crosslink and harden collagen fibers. Dullness, loss of elasticity, and an aged appearance are in large part caused by AGE accumulation. Prevention and suppression are the only strategies.
The FABIR Five-Axis Framework
Five pathways. Five scores. Managed simultaneously.
We refer to these five pathways as the FABIR Framework—Fibroblast, Anti-glycation, Barrier, Inflammation, and ROS.
We quantify how far each axis has degraded, then design formulations that address each pathway specifically. This is the structural foundation of every REGINA LOCUS LVXL product.
Formulation Design Based on FABIR
Current products and pathways in development.
Available
R-axis
Concentré Revitalizon Avancé Base de Liposomes
10% fullerene. Controls ROS—the origin of the aging cascade—at the upstream level. Cuts off the source of senescent cell formation before it begins.
Learn more →Available
B-axis
Sérum Renaissance Beauté
World-highest concentration of Ceradrop. Fundamentally rebuilds the barrier—the first structure to collapse as the aging cascade advances. Restores resistance to external stressors.
Learn more →In Development
I-axis
Anti-Inflammation Lotion
A formulation targeting chronic inflammation. Rather than removing senescent cells after they form, this creates an environment where they do not form at all.
In Development
A+F-axis
Anti-Glycation + Fibroblast Activation Cream
A compound formulation targeting both AGE accumulation suppression and fibroblast activation simultaneously. Addresses damage at the terminal end of the aging cascade.
How We Differ from Senolytics
Upstream control, not downstream cleanup.
Senolytics—the removal of senescent cells—has attracted significant attention. Senescent cells trigger chronic inflammation (SASP) and damage surrounding cells. The approach itself has scientific merit.
But we ask: why do senescent cells form? The answer is chronic inflammation and ROS. REGINA chose to control the source from which senescent cells arise. Upstream control, not downstream cleanup.
Understand the five pathways. Then choose.
Know which pathways the current two products address, and which are coming next.