R + I + B
Available
Mousse Purifiante Lumière
Cleansing
To cleanse is to prepare. A cleanser at the very top of the routine that calms oxidation and inflammation and sets the skin condition that lets what follows work.
¥4,980Learn More →
Why REGINA LOCUS LVXL
Zero advertising. Every yen into ingredients.
Since founding in 2012, this brand has spent nothing on advertising. Every resource goes entirely into ingredient sourcing. We choose formulations honest to the reality of aging, not formulations that sell easily.
2012
Founded
¥0
Advertising spend
100%
Into ingredients
Signature Products
Two honest formulations.
Each directly addresses a distinct mechanism of skin aging.
FABIRS — what the six letters stand for
- F— Fibroblast
- A— Anti-Glycation
- B— Barrier
- I— Inflammation
- R— Antioxidation
- S— Senescent Cell Clearance
The Limits of Conventional Skincare
Why ordinary skincare does not reach deep enough.
01
ROS (Reactive Oxygen Species) Cascade
The oxidative stress-driven destruction of collagen cannot be halted by moisturizers alone. Materials with antioxidant mechanisms are required.
02
AGEs (Advanced Glycation Endproducts) Accumulation
Aging caused by protein glycation cannot be reversed by surface-level care. A structural approach is necessary.
03
Compromised Formulation Concentration
Most products list ingredients but use negligible concentrations. We use only concentrations where efficacy has been confirmed.
The Evidence for Skin Longevity
Aging follows a sequence. Which means it can be addressed in the right order.
ROS → inflammation → MMP → collagen destruction → AGE accumulation → senescent-cell accumulation. Understanding these six pathways is where real skin longevity begins.
The effect of topical application on senescent cells in human skin is an area where verification is still in progress. CHROSNOF treats S as an axis within its calculations and makes no numerical claim regarding amounts removed or states reached.
Understand the Six Pathways →Responding to aging with materials that understand it.
From two formulations, find the one that meets your skin's challenge.