REGINA LOCUS LVXL
JA

Skin Aging Dynamics, Chosen

The science of time, for your skin.

Skin aging dynamics, leading to skin longevity. Skin aging does not arise from a single cause. So we address six pathways, with six scores, simultaneously. That is our answer.

View ProductsSee the order of aging
FABIRS

01 — HOW SKIN AGES

Skin ages in order.

Six processes, each calling up the next — from the fast-moving to the slowly accumulating. And what accumulates at the end pushes the upstream back up.

  1. 01 · Seconds–minutes

    ROxidation

    “Rust”

    UV and stress raise reactive oxygen species.

    Dullness, roughness

  2. 02 · Hours–days

    IInflammation

    “A smouldering fire”

    ROS switches on inflammation.

    Redness, sensitivity

  3. 03 · Days–weeks

    BBarrier loss

    “Gaps in the wall”

    The epidermal wall loosens and moisture escapes.

    Dryness, tightness

  4. 04 · Months–years

    FCollagen breakdown

    “An unravelling net”

    Enzymes unravel the net that holds firmness.

    Loss of firmness, sagging

  5. 05 · Years

    AGlycation

    “Scorch”

    Sugars cling to collagen and stiffen it.

    Yellowing, stiffness

  6. 06 · Decades

    SCellular senescence

    “Old cells that linger”

    Lingering cells scatter sparks and push the upstream back up.

    Sparks spread around them

↻ Here the chain closes into a loop and returns upstream

FABIRS — what the six letters stand for

  • F — Fibroblast ／ 線維芽細胞活性化
  • A — Anti-Glycation ／ 抗糖化
  • B — Barrier ／ バリア強化
  • I — Inflammation ／ 抗炎症
  • R — Antioxidation ／ 抗酸化
  • S — Senescence Control ／ 老化細胞の蓄積抑制

The effect of topical application on senescent cells in human skin is an area where verification is still in progress. CHROSNOF treats S as an axis within its calculations and makes no numerical claim regarding the amount of senescent cells or any end state.

Explore the six pathways →

02 — THE ORDER

Stop the fire and rust. Mend the wall. Reweave the net.

The order of care changes the result.

Stop the fire and rust
Mend the wall
Reweave and prevent build-up

CLEANSE

Mousse Purifiante Lumière Cleanser

The top of the routine. Cleanses while setting the conditions for everything that follows.

Available

  1. STEP 1

    Calm

    Stop the smouldering fire and the rust first.

    • Essence Sérénité Profonde

      Essence

      Coming Soon

    • Concentré Revitalisant Avancé

      Concentrate

      Available

  2. STEP 2

    Protect

    Close the gaps in the wall.

    • Sérum Renaissance Beauté

      Serum

      Available

  3. STEP 3

    Build

    Reweave the unravelled net, and keep scorch and old cells from building up.

    • Crème Régénération Temporelle

      Cream

      In Development

+ INNER

Tisane Lumière Intérieure Tisane

For scorch, rust and old cells — from within, too.

In Development

03 — SIGNATURE

Three honest formulations.

Each directly addresses a distinct mechanism of skin aging.

  • Mousse Purifiante LumièreCLEANSE

    Mousse Purifiante Lumière

    Cleansing

    To cleanse is to prepare. A cleanser at the very top of the routine that calms oxidation and inflammation and sets the skin condition that lets what follows work.

    ¥8,800Learn More →
  • Concentré Revitalisant AvancéSTEP 1

    Concentré Revitalisant Avancé

    Concentrate

    World's highest concentration fullerene 10%. 172x the antioxidant power of Vitamin C.

    ¥12,800Learn More →
  • Sérum Renaissance BeautéSTEP 2

    Sérum Renaissance Beauté

    Serum

    BSB Innovation Awards 2025. World's highest concentration Ceradrop formulation.

    ¥22,000Learn More →

IN DEVELOPMENT

  • Essence Sérénité Profonde

    Essence · STEP 1

    In Development

  • Crème Régénération Temporelle

    Cream · STEP 3

    In Development

  • Tisane Lumière Intérieure

    Tisane · INNER

    In Development
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AdvertisingIngredients

04 — WHY REGINA LOCUS LVXL

Zero advertising. Every yen into ingredients.

Since founding in 2012, this brand has spent nothing on advertising. Every resource goes entirely into ingredient sourcing. We choose formulations honest to the reality of aging, not formulations that sell easily.

Founded
2012
Advertising spend
¥0
Into ingredients
100%
Read Full Concept →

05 — CHROSNOF

Among the six, where is your skin most likely to give way first?

CHROSNOF is our skin-aging analysis method. From your lifestyle data, it identifies which of the six pathways is most likely to dominate, and sets the priorities for your care.

In developmentLearn about CHROSNOF
FABIRS
*Illustrative image

The Limits of Conventional Skincare

Why ordinary skincare does not reach deep enough.

  1. 01

    ROS (Reactive Oxygen Species) Cascade

    The oxidative stress-driven destruction of collagen cannot be halted by moisturizers alone. Materials with antioxidant mechanisms are required.

  2. 02

    AGEs (Advanced Glycation Endproducts) Accumulation

    Aging caused by protein glycation cannot be reversed by surface-level care. A structural approach is necessary.

  3. 03

    Compromised Formulation Concentration

    Most products list ingredients but use negligible concentrations. We use only concentrations where efficacy has been confirmed.

Brand Philosophy

We decided not to make products that sell easily.

Pleasant texture, glamorous advertising, accessible price. We abandoned all of that to choose one thing: honesty with the structure of aging.

Read Full Concept →

Responding to aging with materials that understand it.

From three formulations, find the one that meets your skin's challenge.

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